Pathology: big information from tiny bits
The physical exam is an important part of any clinical evaluation. For a child, getting poked and prodded by a complete stranger can be quite scary. Throughout my rotations I have discovered that pediatricians have quite the arsenal of games and tricks to help get what they require from an exam while keeping the child as comfortable as possible. Ears can be examined while the child is in their parent’s arms. A fun sticker or penlight can keep an infant quiet long enough to listen to their heart and lungs. Having a child talk about this year’s Halloween costume helps them relax their tummy and allow for an abdominal exam.
Fun games and distractions can help disguise a physical exam. In a similar way, sometimes a disease can present appearing to be something else. For example, in the Peds GI clinic they commonly evaluate children who have symptoms of gastroesophageal reflux but have not found relief with diet changes and commonly used medications. Luckily there are plenty of tests available to help clinicians sort through all the potential causes. In this case, one such test in an esophagogastroduodenoscopy (EGD). It looks down the throat with a tiny camera to visualize the esophagus, stomach, and first part of the small intestine. Biopsies can be taken, and these little pieces of tissue can provide clues that point to the underlying cause of a patient’s symptoms.
Each week the Pediatric GI team at U of M has a pathology conference. The team meets with a pathologist to look at biopsies from the previous week. We gather around an elaborate microscope that allows everyone to look at the same slide. In this way the team is able to correlate a patient’s clinical presentation to findings on the histologic (tissue) and cellular level. These conferences are a great refresher of classes from my pre-clinical years, and we’ve seen some interesting cases. It is pretty amazing how quickly the pathologists can pick out seemingly subtle changes under a microscope.
Though more invasive means are required to obtain them, biopsies can provide a more definitive idea of what process is causing a patient’s symptoms. That case of gastroesophageal reflux actually turned out to be eosinophillic esophagitis, a disorder that can present the same way but require different treatment. It seems that it can sometimes take months to find the true cause of a little guy’s discomfort, so it’s a big relief to families to finally get the right diagnosis.
Tags: gastroenterology, michigan, microscope, Mott, pathology, pediatric GI
October 16th, 2009at 1:27 pm
Patrick, your last few blogs have been subpar.
October 18th, 2009at 9:33 am
Pat,
Your blogs are great…your knowledgeable yet sensitive attitude is going to make you a great pediatrician